High Creatinine level : Causes & Treatments

Serum creatinine is a laboratory test that is performed as part of routine blood work and to facilitate diagnosis of kidney disease, not supplement used to gain muscle. Low creatinine levels are a sign of reduced muscle mass, which may be caused by disease, debilitation or aging.

A patient has had elevated creatine over the past several years. Could this be caused by chemotherapy or BP medication? The patient also twitches, which I thought might be attributable to electrolyte imbalance.

Creatine, a naturally occurring amino acid found in meat and fish, is also made in the liver, kidneys and pancreas. It is stored in muscle and plays a major role in energy production. Creatine is broken down to creatinine, which enters the circulation and is excreted by the kidneys.

Elevated creatine may occur with high meat intake, active rheumatoid arthritis, testosterone therapy and any process that results in destruction of muscle. Elevated creatinine can be an indication of kidney disease or can be attributable to such medications as aminoglycosides, penicillins, ACE inhibitors, nonsteroidal anti-inflammatory drugs, and chemotherapy and biological agents. It would be best to follow the levels of both creatine and creatinine in consultation with an oncologist.

Several medical conditions in addition to diabetes are capable of causing increased creatinine levels in the bloodstream, including muscular dystrophy and glomerulonephritis. Pregnant women with preeclampsia or eclampsia may notice higher levels of this substance in their blood. People with obstructions of the urinary tract may develop an increased level. Congestive heart failure or shock can reduce blood flow to the kidneys, thereby raising the levels as well.
High blood pressure, or hypertension, can damage a person’s kidneys and cause unhealthy levels of increased creatinine to build up in the body. Hypertension patients usually need to take blood pressure medications as prescribed by a doctor to maintain normal blood pressure levels. Patients typically should not stop taking their hypertension medications unless they are advised to do so by a doctor.

Often, patients with kidney failure are not able to excrete toxins from their blood. Kidney failure typically requires kidney dialysis treatment to get creatinine levels down to a normal level. People with abnormally high levels may experience fatigue, dehydration, confusion, or shortness of breath.


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