Why Medications Can Cause Kidney Failure

The emergence of kidney failure can affect kidney function, for patients, scientific treatment is very important. Choose a regular treatment, avoid using the wrong medicine, a lot of drugs harm to the kidneys is large, but also lead to a lot sicker drugs easily lead to kidney failure, then why drugs cause kidney failure occurs.

First, the primary kidney patients, as hypovolemia, or decreased blood pressure, the blood supply is reduced renal ischemia and hypoxia state, it has been unable to meet the blood and oxygen needed for normal kidney work. At this time, a large number of drugs into the kidney will increase the sensitivity of drug toxicity, easy to aggravate ischemia, hypoxia caused by endothelial cell damage.

Second, the kidney has a very rich capillary, a large number of drugs with the blood flow into the kidneys, capillary endothelial cells and their larger contact area, resulting in the glomerular capillary endothelial cell damage, also increases the in vivo drug involvement forming antigen - antibody complexes opportunity deposited in glomeruli.

Third, the prototype drug or its metabolites in the urine by glomerular basement membrane after filtration, in the tubule lumen by direct toxic tubular epithelial cells. In addition, subsequent reabsorption and re-excretion process, and increase the role of chance in renal tubular epithelial cells and drugs.

Fourth, when the drug with the urine by glomerular filtration, where the water in the countercurrent multiplication mechanism of action is tubular reabsorption. Jingdong Sino-US nephropathy network of experts pointed out that the drug concentration in the renal tubules gradually increased, especially at higher concentrations of the renal medulla nipple area, so prone to poisoning of kidney damage.

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