Kidney failure is described in two ways: acute or chronic. Acute kidney failure occurs when illness, infection, or injury damages the kidneys. Temporarily, the kidneys cannot adequately remove fluids and wastes from the body or maintain the proper level of certain kidney-regulated chemicals in the bloodstream. Similarly, chronic kidney failure occurs when a number of diseases or inherited disorders injure the kidneys, but this form leads to irreversible damage, and eventually total kidney failure or end-stage renal disease (ESRD). Without proper treatment intervention to remove wastes and fluids from the bloodstream, ESRD is fatal.
The kidneys are the body's natural filtration system. They perform the critical task of processing approximately 200 quarts of fluid in the bloodstream every 24 hours. Waste products like urea and toxins, along with excess fluids,are removed from the bloodstream in the form of urine. Kidney (or renal) failure occurs when kidney functioning becomes impaired. Fluids and toxins beginto accumulate in the bloodstream. As fluids build up in the bloodstream, thepatient with acute kidney failure may become puffy and swollen (edematous) inthe face, hands, and feet. Their blood pressure typically begins to rise, and they may experience fatigue and nausea.
Unlike chronic kidney failure, which is long term and irreversible, acute kidney failure is a temporary condition. With proper and timely treatment, it can typically be reversed. Often there is no permanent damage to the kidneys. Acute kidney failure appears most frequently as a complication of serious illness, like heart failure, liver failure, dehydration, severe burns, and excessive bleeding (hemorrhage). It may also be caused by an obstruction to the urinary tract or as a direct result of kidney disease, injury, or an adverse reaction to a medicine.
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