The Common Causes of Polycystic Kidney Disease

90% of patients with polycystic kidney disease abnormal gene is located on the 16th chromosome short arm, known as polycystic kidney disease 1 gene, the gene product is unclear. Another 10% less than the abnormal gene in patients with short arm of chromosome 4 is located, called polycystic kidney disease 2 gene, which encodes products are also unclear. The two groups in the onset of hypertension appear and enter the age of renal failure vary.

The exact cause of this disease is unclear. Although most symptoms after only adult, but formed in the fetal period begins. Cyst originated in the renal tubules, its liquid properties vary with the site of origin, originated in the proximal tubule, the cyst fluid ingredients such as Na +, K +, Cl-, H +, creatinine, urea and plasma is similar; it originated in the distal within the cyst fluid Na +, K + concentration is low, a high Cl-, H +, creatinine and urea concentrations.

Polycystic kidney disease in patients with glomerular capsule abnormal proliferation of epithelial cells is one of the salient features of polycystic kidney disease, in a mature state of incomplete or re-development, is highly suggestive of cell maturation regulatory obstacles, the cells in a species immature state, thereby displaying strong proliferative. Abnormal epithelial transport is another significant feature of polycystic kidney disease, is closely related to the performance of cellular transport of Na + -K + -ATP enzyme subunit composition, distribution and alter the activity of expression; cell signaling abnormalities and changes in ion transport channels. Extracellular matrix dysplasia is the third significant feature of polycystic kidney disease.

Many studies have shown: These abnormalities are involved in cell growth factor-related activity. But the key links and abnormal ways not yet understood. In short, due to a genetic defect caused the change of cell growth and the formation of interstitial abnormalities, one of the important pathogenesis of disease-oriented.

Among living people only understand the causes polycystic kidney disease, in order to better help people do a good job for polycystic kidney disease prevention. Polycystic kidney disease in real life not only has a relatively high incidence of this disease and after a patient brought to our kidney health hazard is relatively large, so I hope that every patient can pay attention to active treatment and care.