The following content will introduce to you the therapy of Stem Cell Therapy . If you want to know more detail information about this therapy . Read the following content please .
Scientists have found a new method of suppressing the automatic rejection of
donated kidneys in transplant patients, by using the donor's stem cells. In a
small trial carried out at Stanford University, California, eight out of 12
patients were able to stop taking anti-rejection drugs, which are usually a
lifelong necessity, following this treatment.
Soon after their transplants, each of the patients in the study underwent a
procedure where their lymph nodes, spleen and thymus were given a dose of
radiation to kill some of their immune system's white blood cells. This was in
addition to the patient taking the standard course of two anti-rejection
drugs.
About ten days after the radiation treatment, the patient was injected with
stem cells from the donor's blood. They then differentiate into white blood
cells and become part of the recipient's immune system, and will not attack the
new kidney. If the stem cells mix favourably with the patient's own cells, the
patient can be taken off the first anti-rejection drug after a month, and the
second after six months.
'Those eight that we've taken off the drugs, they've had no rejection, no
evidence of the kidney being damaged', said Dr Samuel Strober, the immunologist
who is leading the study, which was published in the New England Journal of
Medicine.
All of the eight patients treated successfully have now been off the
immunosuppressant drugs completely for over a year, including one for over three
years. Dr Strober, explained the other four have 'failed to meet our strict drug
withdrawal criteria', but have suffered no side effects from the treatment.
Currently, all transplant patients need the drug course to prevent their body
from rejecting the donor organ. This is the case even if the donor is a perfect
match in terms of surface markers – called HLA (human leukocyte antigen) antigen
– which reduces the risk of the donated kidney being rejected. However, they can
pose problems in the long-term.
'While they help ward off rejection of the new organ by the patient's own
immune system, these drugs carry their own risk of side effects, such as high
blood pressure, diabetes and cancer', said Dr Strober.
All the patients in this on-going clinical trial are perfect matches with
their donors, but the work is now being expanded to include patients with
mismatched donors, where only 50 percent of their HLA antigens match the
patient's.
'Our preclinical lab results show that we can use mismatched recipients as
well as matched, and that gives us confidence to move ahead', added Dr
Strober.
However, Dr Flavio Vincenti, a kidney transplant expert at the University of
California, San Francisco, cautioned against over-optimism. He said it was not
known whether the delicate balance of the immune system can be maintained in the
long-term. 'I would caution patients and physicians that this gives us maybe an
idea on a mechanism of action, but from a practical point of view, it will have
very limited application', Dr Vincenti told the San Francisco Chronicle.
This therapy have a high risk in the treatment progress . Many doctor will suggestion you don't adopt this therapy .You can adopt Micro-Chinese Medicine Osmotherapy to instead this therapy .Micro-Chinese Medicine Osmotherapy have be proved can treat one's kidney disease efficient .
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